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[125I]-SB258585 binding in the mouse brain. A, Autoradiogram showing total binding of [125I]-SB258585 on a coronal section of a mouse brain, through the rostral part of the corpus striatum. B, Autoradiogram generated over an adjacent section but incubated with [125I]-SB258585 in the presence of 10 μm unlabeled serotonin to define nonspecific binding. C, Displacement of [125I]-SB258585 by increasing concentrations of EMDT and SB271046. Error bars indicate SEM.
