Figure 6.

Comparison of the regulation by EMDT of the phosphorylation states of DARPP-32 and GluR1 in striatal slices from wild-type (WT) and D₁ receptor knock-out (D1 KO) mice. In vitro regulation of Thr³⁴-DARPP-32 (A) and Ser⁸⁴⁵-GluR1 (B) phosphorylation by EMDT (100 μm) in slices of neostriatum from wild-type and D₁ knock-out mice. The amounts of phospho-Thr³⁴-DARPP-32 and phospho-Ser⁸⁴⁵-GluR1 in extracts of slices were quantified by densitometry. Data represent means ± SEM (n = 6–12). *p < 0.05 compared with wild-type control; ⁺p < 0.05 compared with D₁ knock-out control; unpaired two-tailed Student's t test.