Figure 7.

Regulation by EMDT of the phosphorylation states of DARPP-32 and GluR1 in striatal and cortical extracts from intact mice. Regulation of Thr³⁴- and Thr⁷⁵-DARPP-32 and Ser⁸³¹- and Ser⁸⁴⁵-GluR1 phosphorylation in vivo in the striatum (A–D) and frontal cortex (E, F) by EMDT. Mice were injected intraperitoneally with saline or EMDT (5 mg/kg). Fifteen minutes later, mice were killed by focused microwave irradiation. Data represent means ± SE for 5–10 mice per group. *p < 0.05 compared with saline-treated mice; one-way ANOVA followed by Newman–Keuls test.