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. 2019 Jun 8;22(8):523–527. doi: 10.1093/ijnp/pyz031

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© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Alcohol withdrawal-induced hyperalgesia is blocked by suberoylanilide hydroxamic acid (SAHA). (A) Mechanical responses remained stable throughout ethanol or control treatment. During the withdrawal period, control diet and withdrawal groups were injected daily with SAHA (50 mg/kg i.p.) or vehicle following ethanol withdrawal, while the ethanol-maintained group was concurrently injected with vehicle. (B) At 24-hour withdrawal, there was a significant difference between withdrawn animals and ethanol (P < .05) and control groups (P < .05). (C) Repeated injection of SAHA significantly reduced this hyperalgesia by 72-hour withdrawal; n = 8/group, **P < .01, ***P < .001 compared with the control-VEH group (2-way repeated-measures ANOVA with Holm Sidak post-hoc analysis).