Figure 6.

Probenecid and RO201724 have the same effect to reverse the cocaine-induced impairment of DCG-IV-LTD. A, B, Summary of experiments in which probenecid (200 μm) was applied before the induction of LTD by application of DCG-IV (0.2 μm) in slices from rats treated with saline (A) or cocaine (B) for 5 d. C, D, Summary of experiments in which RO201724 (200 μm) applied before application of DCG-IV in slices from rats treated with saline (C) or cocaine (D) for 5 d. E, Summary of experiments showing coapplication of RO201724 (200 μm) blocked the inhibitory action of FSK (25 μm) and DPCPX (0.2 μm) on the induction of DCG-IV-LTD. Error bars indicate SEM.