Figure 10.

Sei neuron pools in different genetic backgrounds. A, The Sei neuron pool in wild type and the top1^JS mutant. Excitatory and inhibitory neurons are balanced in the Sei neuron pool, although the top1^JS Sei neuron pool contains more neurons than the wild-type because of its seizure-resistant property. B, The Sei neuron pool in the eas mutant and top1^JS eas double mutant. Excitatory neurons are more prevalent than inhibitory neurons in the Sei neuron pool because of the seizure-sensitive property of eas mutant background. The dot-circled area represents the neurons involved in seizure generation, because lower seizure thresholds are required in eas and top1^JS eas than the wild type and top1^JS.