Figure 6.

Seizure suppression in bss flies. A, Behavioral bang sensitivity is reduced in bss/+ heterozygous flies in the presence of top1^JS. Note that bss/+ flies show 100% bang sensitivity; however, when it is placed in a top1^JS homozygous background, behavioral bang sensitivity is reduced to 12% (p < 0.01). B, The recovery time is shortened in double-mutant top1^JS bss flies. The bss mutant has an average paralysis time of 120 s, whereas the double-mutant top1^JS bss shorten the paralysis time to 77 s. Shown is the percentage of flies recovered with time and a cumulative measure that includes the initial behavior seizure, the paralysis period, and the recovery seizure, which are not indicated separately. The number of flies standing at intervals after the shock was recorded until the entire population had recovered. For behavioral bang-sensitivity test, n ≥ 50 flies tested; for the recovery time, n ≥ 30 flies recorded.