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. 2007 Mar 14;27(11):2927–2937. doi: 10.1523/JNEUROSCI.3944-06.2007

Figure 8.

Figure 8.

The top1JS mutation causes apoptosis. A, B, TUNEL assay. Representative sections from adult brain of wild-type (A) and top1JS mutant (B) flies. White indicates TUNEL signal. Weak diffuse TUNEL is observed in wild type. In mutant, TUNEL signal is more widespread and intense. C, DNA analysis by 1.5% agarose gel electrophoresis of genomic DNA. Lane 1, DNA ladder, 1 kb (Fermentas, Hanover, MD). Lane 2, Genomic DNA from wild-type flies. Lane 3, DNA from top1JS eas double-mutant flies. Lane 4, DNA from top1JS mutant flies. Fragmentation is observed in mutant DNA.