Figure 2.

Tonic inhibition in granule cells of control and pilocarpine-treated mice. A, The two raw traces at the top originate from a granule cell each recorded in slices obtained from a control and a pilocarpine-treated (Pilo) mouse, respectively. The tonic currents were measured as described in Materials and Methods. The horizontal bar indicates the perfusion of saturating concentrations of SR 95531 (gabazine) to block both tonic and phasic conductance. B, The box plots summarize the average tonic currents recorded in the two preparations in symmetrical Cl⁻ concentrations at a holding potential of −70 mV. For each box plot, the asterisks represent the two outliers, and the □ within the box is the mean. The error bars represent SEM, and the top and bottom boundaries of the box depict the 75 and 25% of the distribution, respectively. There is no significant difference between the mean tonic currents recorded in the two preparations.