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. 2007 Jul 11;27(28):7459–7468. doi: 10.1523/JNEUROSCI.1483-07.2007

Figure 5.

Figure 5.

Sites of TRPV1 desensitization in RTX-pretreated rats. The sensitivity of TRPV1 channels in different bodily compartments was determined in vehicle-pretreated rats, in rats pretreated with a low desensitizing dose (20 μg/kg, i.p.) of RTX, and in rats pretreated with a high dose (200 μg/kg, i.p.) of RTX. Five tests were performed: the eye-wiping test (determines the sensitivity of TRPV1 channels in the eye); the centrally induced tail-vasodilation test (determines the sensitivity of TRPV1 channels in the brain); the Bezold–Jarisch reflex test (determines the sensitivity of TRPV1 channels in the heart and lungs); the hot-plate test (assesses the sensitivity of TRPV1 channels in the skin, primarily of the paws); and the writhing test (determines the sensitivity of TRPV1 channels in the peritoneal cavity). For methodological details, see Materials and Methods. The results of all tests are summarized in the schematics at the bottom.