Table 1.
Clinical Characteristics of the Sample
| aMDD | Subsample (aMDD) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rMDD | HC | total | P | aMDDnon-rem | aMDDrem | P | |||||
| n | 28 | 22 | 20 | 10 | 10 | ||||||
| Age | 26.6 ± 5.7 | 25.9 ± 6.7 | 30.5 ± 9.6 | * | 30.5 ± 11.5 | 30.4 ± 6.6 | .49 | ||||
| Sex (f/m) | 16/12 | 12/10 | 14/6 | * | 7/3 | 7/3 | — | ||||
| TIV (MRI-1, cm3) | 1490.3 ± 133.4 | 1453 ± 133 | 1416.1 ± 139.1 | * | 1411.3 ± 123.7 | 1420.8 ± 159.7 | .45 | ||||
| Handedness (r/l) | 28/0 | 22/0 | (19/1) | ||||||||
| Previous medication (relation yes/no) | 1:1 | — | 1:1 | ||||||||
| Age at first episode (y) | 22 ± 5 | — | 22.8 ± 11.7 | 26 ± 12.2 | 20.1 ± 9.7 | .046 | |||||
| Previous episodes (n) | 1.6 ± 1.4 | — | 2.9 ± 1.5 | * | 2.2 ± 0.97 | 2 ± 0.82 | .12 | ||||
| Duration of last (rMDD)/ current (aMDD) episode (months) | 8.3 ± 5.4 | — | 10.1 ± 9 | * | 6.4 ± 6.3 | 9.6 ± 18 | .21 | ||||
| MRI-1 | MRI-2 | MRI-1 | MRI-2 | P | MRI-1 | MRI-2 | P | ||||
| HAM-D24 | 2.3 ± 2.8 | — | 27.2 ± 7.5 | 9 ± 6.9 | * | 27.1 ± 9.6 | 14.4 ± 5.7 | * | 27.3 ± 5 | 3.6 ± 1.8 | * |
| HAMA | 2.6 ± 2.7 | — | 21.3 ± 6.4 | 6.8 ± 5.3 | * | 21.7 ± 8.5 | 10.7 ± 4.8 | * | 20.8 ± 3.9 | 2.8 ± 1.5 | * |
| BDI | 4.2 ± 4.9 | — | 20.6 ± 8.1 | 8.1 ± 5.8 | * | 22.3 ± 9 | 11.5 ± 6.1 | * | 18.9 ± 7.2 | 4.7 ± 3 | * |
| CGI | 1.5 ± 0.5 | — | 5.1 ± 0.7 | 3.5 ± 1.2 | * | 5.2 ± 0.4 | 4 ± 0.5 | * | 5 ± 0.8 | 3 ± 1.4 | * |
Abbreviations: aMDD, acute depressed patients; aMDnon-rem; acute MDD patients nonremitting after treatment; aMDDrem, acute depressed patients remitting; BDI, Beck Depression Index; CGI, Clinical Global Impression Scale; HAM-D24, Hamilton Depression Rating Scale; HC, healthy controls; rMDD, remitted depressed subjects; TIV, total intracranial volume. *P < .001; P values from F-tests (ANOVA), chi-square test, or t test.