Figure 2.

Irreversibility of hypersomnolence and sleep propensity in mice after long-term exposure to hypoxia/reoxygenation, modeling sleep apnea. A, Despite a recovery opportunity of 6 months, total wake times in 24 h (dark hatched bar) remain significantly less than age-matched control (sham treated; light hatched bar). NREMS, Non-rapid eye movement sleep. B, Multiple sleep latency test values remain reduced across unperturbed sleep–wake cycles at the end of the rest period and also after 6 h of sleep deprivation for the same circadian time periods. The asterisks denote significant (p < 0.05) differences relative to sham hypoxia/reoxygenation-exposed mice.