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Tolbutamide differentially depolarizes and diazoxide hyperpolarizes GnRH neurons from oil- and estrogen-treated, ovariectomized female mice. A, Representative recordings from estrogen-treated female showing that tolbutamide induced a depolarization of 6 mV in one cell and diazoxide a hyperpolarization of 12 mV in another cell. B, Summary of the effects of tolbutamide and diazoxide on membrane potentials in GnRH neurons from oil- and estrogen-treated females (n = 5; **p < 0.01).
