Figure 7.

Schematic model of Reelin-dependent control of synaptic NMDAR maturation. Synaptic maturation between 8 and 10–12 div involves a loss of highly ifenprodil-sensitive NMDARs and an accumulation of Reelin at active synapses (dark gray). Addition of rRln to early synapses accelerated maturational processes, i.e., the loss of synaptic NR1/NR2B receptors. This was accompanied by changes in dwell time and diffusion coefficient of 2B–NMDARs. Blocking Reelin function at later stages (i.e., 10–12 div) had opposite effects, resulting in the recovery of synaptic NR1/NR2B receptors and a simultaneous decrease of their synaptic dwell time and an increase of their diffusion coefficient.