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. 2007 Sep 19;27(38):10185–10195. doi: 10.1523/JNEUROSCI.2757-07.2007

Figure 5.

Figure 5.

The NMDAR NR2B subunit antagonist, Ro25-6981 (Ro), partially restores the altered basal hippocampal activity induced by L-IFD. A, Averages of the relative power spectra of CA1 pyramidal layer field activity during exploratory behavior of AL and L-IFD mice 30 min after administration of either vehicle or Ro25-6981 (5 mg/kg, s.c.). Inset, Two-second samples of basal field activity recorded in AL and L-IFD mice under the same conditions (black for AL and gray for L-IFD mice). B, Relative spectral power (mean ± SEM) of low-theta and theta bands in AL and L-IFD mice 30 min after administration of either vehicle or Ro25-6981 (5 mg/kg, s.c.). C, Basal excitatory neurotransmission was measured using paired-pulse facilitation with interpulse intervals from 50 to 200 ms in the presence or absence of Ro25-6981. Bars represent the percentage of maximum paired-pulse facilitation as a function of interpulse interval in AL and L-IFD mice (n = 6 for each group). PP, Paired pulse. **p ≤ 0.01; ***p ≤ 0.001.