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. 2007 Sep 19;27(38):10185–10195. doi: 10.1523/JNEUROSCI.2757-07.2007

Figure 6.

Figure 6.

Ro25-6981 (Ro) reverses the facilitation of synaptic plasticity induced by L-IFD. A, A single HFS train [arrow; five pulses (200 Hz, 100 ms) at a rate of 1/s] evokes an LTP at the CA3–CA1 synapse that lasts for up to 2 h in L-IFD mice (gray circles). Ro25-6981 administration (gray squares) reverses this effect but does not affect the same synapse in AL mice (black circles and squares). B, Summary of percentage change in fEPSP slope (mean ± SEM) at different times after a single HFS train in AL and L-IFD mice, in either the presence or absence of the specific NR2B antagonist. C, Three HFS trains (arrows) induce an indistinguishable LTP (lasting >2 h) in AL and L-IFD mice, in either the presence or absence of Ro25-6981. D, Summary of the percentage change in fEPSP slope (mean ± SEM) at different times after three HFS trains in AL and L-IFD mice, in either the presence or absence of the specific NR2B antagonist (n = 6 for each group). *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.