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. 2007 Sep 19;27(38):10185–10195. doi: 10.1523/JNEUROSCI.2757-07.2007

Figure 7.

Figure 7.

Ro25-6981 (Ro) reverses learning and consolidation facilitation induced by L-IFD. A, B, Administration of Ro25-6981 before each training session blocks the facilitation of trace eyeblink classical conditioning (A) and object recognition memory (B) induced by L-IFD. AL mice were not affected by Ro25-6981 administration. C, The effects of Ro25–6951 infusion directly in hippocampus or perirhinal cortex of AL and L-IFD mice before a 5 min training session were evaluated for the object recognition memory test. Also, schematic representation of cannula localization in hippocampus (top) and perirhinal cortex (bottom) is shown. D, Administration of Ro25-6981 after STM test with a 5 min training in the object recognition memory paradigm blocks memory consolidation in L-IFD mice (n = 8 and 10 mice per group for eyeblink classical conditioning and ORM, respectively). *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. Hp, Hippocampus; PRN, perirhinal cortex; sal, saline.