Figure 4.

Postinjury sulforaphane administration decreases blood–brain barrier permeability after TBI. A, Time course of EB dye extravasation after TBI in sham and injured animals. Administration of sulforaphane 6 h after injury significantly decreases EB extravasation measured at both 24 h and 3 d. B, Six hours postinjury administration of sulforaphane significantly decreases the BBB permeability to a low-molecular-weight compound (fluorescein) at 24 h after injury. C, Sulforaphane at 5 mg/kg, but not 1 mg/kg, is able to attenuate EB extravasation at 24 h after injury. *p < 0.05 compared with injury–vehicle group. Veh, Vehicle; SUL, sulforaphane.