Figure 3.

REST-binding sites are not restricted to the promoter regions of target genes. A, Diagrams showing REST GSTs colocalized with RE1 sites for four distinct transcripts. The position of each RE1 site (star) is shown relative to the SACO GSTs and the transcriptional start sites (arrows). Introns are represented by solid lines, exons are represented by black boxes, and intergenic regions are represented by dotted lines (University of California, Santa Cruz, Mm5 build). Chr, Chromosome. B, Locations of the 893 SACO-identified RE1 sites within 50 kb of putative target genes.