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. 2007 Jun 20;27(25):6684–6691. doi: 10.1523/JNEUROSCI.0934-07.2007

Figure 6.

Figure 6.

Asynchronous release accumulates during repetitive afferent activity. A, B, Representative voltage-clamp traces during short (four pulse) trains at 20 (A) and 50 Hz (B). Top traces are control and bottom traces are after application of 25 μm EGTA-AM. Stimulation artifacts have been removed for clarity. C, Quantification of these data show that asynchronous charge transfer elicited by 20 and 50 Hz trains in control was 2.53 ± 0.44 pC and 2.79 ± 0.47 pC, respectively. After application of 25 μm EGTA-AM, asynchronous release was 1.28 ± 0.21 pC and 1.39 ± 0.20 pC for the 20 and 50 Hz trains respectively (*p < 0.05; n = 5). D, The synchronous component of release during the trains was not inhibited after EGTA-AM (20 Hz control, 2.23 ± 0.58 pC; 20 Hz EGTA-AM, 2.01 ± 0.60 pC; p > 0.05; 50 Hz control, 2.28 ± 0.52 pC; EGTA-AM, 1.94 ± 0.61 pC; p > 0.05; n = 5).