Figure 1.
Learning and LTM defects, but normal ARM in Nf1-null mutants. A, Learning and LTM defects in Nf1 mutants. Compared with the K33 (control) parental group, the Nf1P1 and Nf1P2 mutants display significantly lower performance (*p < 0.001) in learning (one cycle training) and in LTM (spaced training; for details, refer to Materials and Methods). B, Normal ARM performance in Nf1 mutants. Memory performance was tested 24 h after massed training. Nf1 mutants perform similar to the parental K33 (control) flies after massed training. This indicates that the 24 h memory defect observed in these mutants is in fact an LTM defect because ARM is normal. PI scores are expressed as mean ± SEM, n = 8.