Figure 5.

Rescue of learning by Cterm fragment. Flies expressing Cterm (see Fig. 3 A) exhibit complete rescue of learning compared with the wild-type transgene (*p < 0.001), whereas the N-terminal fragment (Nterm) (see Fig. 3 A) has no effect on the learning score (left). Both fragments are unable to restore LTM performance (right). These data indicate region-specific functionality of the NF1 protein for distinct memory phases (i.e., the GRD is required for LTM) and the C-terminal is essential for learning. PI scores are expressed as mean ± SEM, n = 8.