Figure 4.

Effects of ACPT-I, DCPG, and CPPG injections into the substantia nigra pars reticulata on haloperidol-induced catalepsy. A, B, Animals (n = 5–7 per group) received intranigral injections of ACPT-I (0, 0.25, 1 nmol/μl) or mGluR8-selective agonist DCPG (0.1 nmol/μl) 85 min after haloperidol (1 mg/kg) administration (A) or after saline injection (B). Catalepsy was measured immediately after intranigral injections and every 10 min for the 1 h testing. The group III mGluR antagonist CPPG (10 nmol/μl) was injected 10 min before ACPT-I or vehicle. The data are expressed as mean median latency ± SEM during the total duration of the test. *Significantly different from control group (p < 0.05; significant Mann–Whitney U test). ^#Significantly different from haloperidol group (p < 0.05; significant Mann–Whitney U test).