Table 1.

Expression of AMPA receptor subunits in human glioma

	Immunohistochemistry				RT-PCR				E	Histology
	R1	R2	R2/R3	R4	R1	R2	R3	R4
Surgical specimen
GNS-3000	+++	+	+	++						GBM
GNS-3114	++	++	++	+++	+	+	+	+	Q/R	GBM
GNS-3148	++	+/−	+/−	++						GBM
GNS-3186	++	+	+	++						GBM
GNS-3195	++	+	+	++						GBM
GNS-3199	++	+	+	++						GBM
GNS-3210	+++	+	+	+++						GBM
GNS-3226	++	+	+	++						GBM
GNS-3243	++	++	++	+++						GBM
GNS-3245	++	+	+	++	+	+	+	+	R	GBM
GNS-3262	++	+	+	++						GBM
GNS-3275	++	+	+	++						GBM
GNS-3296	++	+	+	++						GBM
GNS-3314	+++	+	+	+++	+	+	+	+	R	GBM
G-22	+	−	−	+						GBM
G-87535	++	−	−	+						GBM
GNS-4167	+++	++	++	++	+	+	+	+	R	GBM
GNS-828	++	++	+	++	+	+	+	+	Q/R	AA
Cell culture
GNS-3245	+++	−	+	+	+	−	+	+		GBM
GNS-3296	++	+	+	++	+	+	+	+	R	GBM
GNS-3302	+++	+	+	+++	+	+	+	+	R	GBM
GNS-3314	+++	++	++	+++	+	+	+	+	R	GBM
G-98	+++	+	+	+	+	+	+	+	R	All
GNS-3901	++	+	++	++	+	+	+	+	R	All
GNS-6330	++	+	++	++	+	+	+	+	R	AA
GNS-828	++	++	+	++	+	+	+	+	Q/R	AA
G-151	+++	+	+	+	+	+	+	+	R	AA
GNS-2093	++	++	+	++	+	+	+	+	R	AA
Cerebellar astrocytes	+	−	−	+	+	−	−	+		a
Cerebral astrocytes	−	+	+	−	−	+	+	−	R	b
Cell line
CGNH-89	++	−	−	++	+	−	−	+		GBM
CGNH-NM	++	−	+	−	+	−	+	−		GBM
CGNH-PM	+++	−	−	+	+	−	−	+		GBM
U87-MG	+	+	++	−	+	+	+	−	Q/Rc	GBM
C6	++	++	+	++	+	+	+	+	R	GBM

In immunohistochemistry, +++, ++, +, +/−, and − indicate high, moderate, low, faint, and no expression, respectively. In RT-PCR, + and − indicate that the digested bands were detected and not detected, respectively. Editing status (E) of GluR2 mRNA is shown as R (edited form) or Q/R (unedited and edited form). GBM, AA, and All indicate glioblastoma, astrocytoma, and astrocytoma grade II, respectively.

^aRat cerebellar fusiform Bergmann glia-like cells (Ishiuchi et al., 2001).

^bRat cerebral flat type 1-like astrocytes (McCarthy and de Vellis, 1980).

^cReported by Yoshida et al. (2006).