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. 2007 May 23;27(21):5664–5671. doi: 10.1523/JNEUROSCI.0613-07.2007

Figure 2.

Figure 2.

DHPG enhances the rate of spontaneous IPSCs in mitral cells. A, Bath application of DHPG (20 μm) greatly increases the occurrence of spontaneous IPSCs in mitral cells. Addition of DHPG in general evoked a slow inward or outward current followed by a rapid transition to a high rate of IPSCs. Traces on the bottom of A show expanded versions of the control and DHPG conditions. B, Cumulative probability plot of interevent intervals for control and DHPG conditions (n = 6). Inset shows mean event rate for the two conditions (control, 0.41 ± 0.2 Hz; DHPG, 5.86 ± 1.26 Hz; n = 6; p < 0.01). C, Cumulative probability plot of event amplitudes for control and DHPG conditions indicating no significant differences. Inset shows average IPSC waveforms for each of the conditions. D, Mean increase in IPSC rate across all mitral cells (n = 6). The mean trace was generated from normalized and aligned sigmoid fits to plots of IPSC rate versus time, as described in the text. Error bars indicate ±SEM. E, Examples of sigmoid fits to IPSC event rates for three representative mitral cells. F, Raw data of the cell indicated by the gray line in E (different cell than in A). Data segment is 20 s after the earliest observed increase in IPSC event rate (as defined in Materials and Methods). Ctrl, Control.