Figure 3.

Effects of mAChR blockade by intracerebroventricular injection of atropine on the endogenous V1 spindle bursts in the retinas-ablated pups. A, Extracellular field potential recordings from ipsilateral (black trace) and contralateral (gray trace) V1 of a P6 rat under control conditions (both retinas removed), after injection of 1 μl of ACSF, and after injection of 1 μl of atropine (10 μg/g body weight, in ACSF). Inset, Typical spindle bursts displayed at expanded time scale and averaged power spectrum of the field potential oscillations corresponding to the displayed traces. Note that atropine reduced the occurrence of endogenous spindle bursts. B, Bar diagram displaying the effects of intracerebroventricularly applied atropine on the occurrence of bursts on the ipsilateral (black bars) and contralateral (gray bars) V1 of five P5–P6 pups. The hemisphere of intracerebroventricular injection was defined as ipsilateral.