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. 2007 May 23;27(21):5694–5705. doi: 10.1523/JNEUROSCI.5233-06.2007

Figure 4.

Figure 4.

Effects of intracortical injection of atropine on the V1 spindle bursts elicited by ON stimulation. A, Averaged ON-evoked cortical responses (1; i) followed by individual spindle bursts (2; ii) in response to electrical stimulation (black arrow) of the contralateral ON in a P5 pup under control conditions. Note the various amplitude and duration of the ON-induced spindle bursts. Aiii, Power spectra of the single ON-induced V1 spindle bursts shown in ii. B, Averaged direct cortical responses (1; i) followed by individual spindle bursts (2; ii) in response to electrical stimulation (black arrow) of the contralateral ON in a P5 pup after intracortical injection of 50 nl of atropine (10 μg/g body weight, in ACSF; coordinates of injection on the recorded side, −2 mm anterior to bregma, 2.5 mm lateral to midline, and 400 μm below the pial surface). Note that atropine had no effect on the direct response, but diminished the ON-induced spindle bursts. Biii, Power spectra of the single ON-induced V1 spindle bursts shown in ii. C, Bar diagram displaying the relative onset, amplitude, and duration of the ON-induced direct response (1) in the presence of atropine when compared with controls (100%). D, Bar diagram displaying the properties of ON-induced spindle bursts in the V1 of five pups before and after intracortical injection of atropine on the recorded hemisphere.