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. 2007 May 23;27(21):5812–5822. doi: 10.1523/JNEUROSCI.0491-07.2007

Figure 1.

Figure 1.

Behavioral and physiological deficits after C7/8 DRI partially recover in the absence of mechanosensory axon sprouting. a, Time to detect a sticker on the palm in sham-operated and C7/8 DRI rats. In rhizotomized animals, all postoperative ipsilateral (ipsi)–contralateral (contra) latencies differed significantly. b, Electrophysiological assessment of functional deficits and recovery. Left, Experimental setup and a sample trace from a single channel of the electrode array. Right, Feature space plots in various experimental conditions (Borisoff et al., 2006). Acute C7/8 rhizotomy decreased the discrimination of digit simulation clusters. Ten days after C7/8 DRI, all clusters were distinct, and the probability of correctly classifying evoked responses as being from separate digits was restored. Principal component (PC) axes are indicated. Asterisk indicates significant reduction in probability of correct digit classification. c, C7/8 DRI produces a prominent deafferentation gap in VGLUT1- and CTB-positive terminals in the C7 dorsal horn (box); density did not change therein for 20 d after injury. The arrow points to spared C6/T1 axons. Scale bar, 100 μm.