Figure 3.

Sequestration of injury-induced BDNF promotes complete mechanosensory recovery after C7/8 DRI. a, Fc immunohistochemistry demonstrating spinal penetration of intrathecally delivered proteins. Scale bar, 100 μm. b, Only continuous TrkB-Fc treatment improved mechanosensation. c, Mechanical allodynia did not emerge in IgG- or TrkB-Fc-treated rats, and withdrawal thresholds were increased with TrkC-Fc treatment. Asterisks in b and c indicate significant ipsilateral (ipsi)–contralateral (contra) differences.