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MCM and ACM induce similar responses through p75NTR in mature MN cultures. MNs were cultured in ACM for 2 DIV, rinsed, and either MCM or ACM was reapplied in the presence of anti-p75NTR, and viability was determined at 5 DIV. Treatment with anti-p75NTR resulted in a reduction in MN survival by ∼45% in response to both MCM and ACM (***p < 0.001; ANOVA with Tukey–Kramer post hoc test; n = 4).
