Table 2.
Effects of individual synaptic blockers on spontaneous activity parameters of DA cells
| Group | Firing rate (Hz) | Burst frequency (Hz) | Bursting spikes (%) | Time spent bursting (%) | Spikes per burst | Burst duration (ms) | Intraburst frequency (Hz) |
|---|---|---|---|---|---|---|---|
| Control | 6.1 ± 1.2 | 0.45 ± 0.10 | 57.4 ± 13.3 | 15.4 ± 3.1 | 7.5 ± 1.6 | 343 ± 46 | 24.3 ± 8.5 |
| CNQX (n = 4) | 6.6 ± 1.3 | 0.46 ± 0.16 | 47.5 ± 14.6 | 14.2 ± 3.3 | 6.9 ± 1.1 | 340 ± 48 | 22.7 ± 7.1 |
| Control | 5.5 ± 1.5 | 0.35 ± 0.08 | 55.3 ± 19.3 | 10.6 ± 3.3 | 8.2 ± 4.1 | 260 ± 45 | 28.3 ± 9.2 |
| AP-7 (n = 3) | 6.7 ± 2.5 | 0.40 ± 0.17 | 46.4 ± 21.5 | 11.9 ± 5.7 | 7.5 ± 3.2 | 268 ± 30 | 26.4 ± 8.9 |
| Control | 6.3 ± 0.7 | 0.66 ± 0.07 | 58.1 ± 6.3 | 20.9 ± 3.7 | 6.4 ± 0.5 | 366 ± 37 | 18.3 ± 1.7 |
| GABAzine (n = 7) | 7.3 ± 0.6 | 0.60 ± 0.04 | 70.8 ± 4.0 | 26.0 ± 2.0 | 8.8 ± 1.4 | 438 ± 40* | 20.2 ± 2.4 |
| Control | 6.5 ± 0.9 | 0.54 ± 0.09 | 61.5 ± 9.7 | 19.4 ± 4.6 | 7.6 ± 1.6 | 331 ± 31 | 21.9 ± 4.1 |
| Strychnine (n = 7) | 7.9 ± 1.5 | 0.53 ± 0.11 | 76.1 ± 9.9* | 21.4 ± 5.6 | 11.7 ± 1.7* | 457 ± 39* | 24.5 ± 2.7 |
*p < 0.05.