Skip to main content
. 2007 Jan 17;27(3):627–633. doi: 10.1523/JNEUROSCI.4849-06.2007

Figure 4.

Figure 4.

Decreased amyloid deposition in BRI-Aβ40/BRI-Aβ42A mice. A, Serial cerebellar sections from 8-month-old mice were immunostained with 33.1.1 (anti-Aβ1-16; top panels) and stained with ThioS (bottom panels). Scale bar: top panels, 200 μm; bottom panels, 50 μm. B, Both the Aβ plaque burden (p = 0.007; t test) and the number of ThioS-positive plaques (p < 0.001; t test) were significantly reduced in BRI-Aβ40/BRI-Aβ42A mice compared with age-matched BRI-Aβ42A littermates. C, Similarly, RIPA-insoluble, FA-extractable Aβ42 levels in the cerebellum of BRI-Aβ40/BRI-Aβ42A mice were markedly lower compared with BRI-Aβ42A littermates (p = 0.01; t test). D, Both the severity of CAA and the number of CAA-affected vessels in cerebellar leptomeninges were reduced in BRI-Aβ40/BRI-Aβ42A mice compared with BRI-Aβ42A mice (p < 0.001; rank sum test). There was no amyloid pathology, CAA, or accumulation of RIPA-insoluble FA–Aβ in BRI-Aβ40 mice.