Table 2.

Correlation between pathological and clinical markers of the Religious Orders Study Cohort

Pathological parameter	MMSE score		Global cognitive score
	NCI, mAD, sAD	MCI, mAD, sAD	NCI, mAD, sAD	MCI, mAD, sAD
VGluT PB density	r = 0.44*; p < 0.01	r = 0.57*; p < 0.0001	r = 0.34; p < 0.05	r = 0.46*; p < 0.001
Amyloid plaque load	r = −0.42; p < 0.01	r = −0.42; p < 0.01	r = −0.43*; p < 0.01	r = −0.44; p < 0.001
NFT load	r = −0.35; p < 0.05	r = −0.33; p < 0.05	r = −0.38; p < 0.01	r = −0.36; p < 0.01
Neuritic plaque number	r = −0.31; p < 0.05	r = −0.31; p < 0.05	r = −0.34; p < 0.05	r = −0.34; p < 0.05
Diffuse plaque number	r = −0.27; p > 0.05	r = −0.14; p > 0.05	r = −0.30; p < 0.05	r = −0.15; p > 0.05
NFT number	r = −0.40; p < 0.01	r = −0.42; p < 0.01	r = −0.41; p < 0.01	r = −0.43; p < 0.01

PB, Presynaptic bouton; NFT, neurofibrillary tangle; r, Pearson correlation factor;

*represents strongest correlation across parameter of interest.