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. 2007 Oct 3;27(40):10912–10917. doi: 10.1523/JNEUROSCI.1869-07.2007

Figure 5.

Figure 5.

Chronic treatment with CX546 restores normal breathing frequency and minute volume/weight in P35 Mecp2 null mice. A, B, Representative histograms of breathing frequency (A) and minute volume/weight (B) from two mutant mice, one treated with vehicle (9227 breath cycles) and one treated with CX546 (8393 breath cycles), showing that drug treatment (40 mg/kg, b.i.d for 3 d) decreases episodes of high breathing frequency and minute volume/weight. C, D, Summary data for breathing frequency (C) and minute volume/weight (D) for all animals. Ampakine treatment completely restores wild-type frequency and minute volume/weight in mutant animals and has no effect in wild types. Results are the mean ± SEM (n = 8 for vehicle-treated wild types; n = 7 for CX546-treated wild types; n = 8 for vehicle-treated mutants; n = 9 for CX546-treated mutants). *p < 0.05; **p < 0.01, ANOVA I with post hoc Tukey's test. BPM, Breaths per minute.