Figure 2.

GluR1^−/− mice exhibit a decreased AMPA/NMDA ratio of evoked synaptic transmission at thalamo- and cortico-LA synapses. a, Placement of stimulation and recording electrodes. b, Sample traces depicting evoked EPSC waveforms at thalamo- and cortico-LA synapses recorded at −70 mV and at +30 mV in wild-type, GluR1^−/−, and GluR3^−/− mice. The AMPA component was obtained by measuring the EPSC peak amplitude at −70 mV; the NMDA component was determined by measuring the current amplitude at 100 ms after EPSC onset at +30 mV (arrows). c, Averaged data illustrating the significant (p < 0.05) reduction in the AMPA/NMDA ratio at cortical and thalamic afferents in GluR1^−/− mice. Number of experiments is indicated on bars. *p < 0.05. Error bars indicate SEM.