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. 2007 Oct 10;27(41):10947–10956. doi: 10.1523/JNEUROSCI.2603-07.2007

Figure 8.

Figure 8.

Comparable CS and US reactivity in wild-type, GluR1−/−, and GluR3−/− mice. a, Mean infrared activity (IR) levels for the 4 s period before presentation of the first CS during conditioning, and the 4 s period of CS presentation does not differ between WT, GluR1−/−, and GluR3−/− mice. Activity scores averaged across 0.5 s time bins (WT, n = 13; GluR1−/−, n = 9; GluR3−/−, n = 9; p > 0.05). A two-way ANOVA of the activity data revealed no main effect of genotype (F(2,28) = 2.52; p > 0.09). There was a main effect of phase (ITI vs CS; F(1,28) = 13.58; p < 0.01), main effect of time bin (F(1,28) = 14.16; p < 0.01), and a significant interaction between these factors (F(3,84) = 3.54; p < 0.05), but no interactions involving genotype. The test of simple main effects revealed a significant effect of time bin only during the CS period (F(3,84) = 7.83; p < 0.001) that reflected a gradual rise in locomotor activity during the CS for all genotypes, suggesting that all genotypes were able to detect the presentation of the tone. b, Comparable activity levels of wild-type, GluR1−/−, and GluR3−/− animals for the 1.25 s period after presentation of the first shock. Activity scores averaged across 0.25 s time bins (WT, n = 13; GluR1−/−, n = 9; GluR3−/−, n = 9; p > 0.05). A two-way ANOVA with genotype and time bin as factors revealed no main effect of genotype (F(2,28) = 2.36; p = 0.1121). However, there was a main effect of time bin, which reflected a reduction in locomotor activity after offset of the shock (F(4,112) = 10.01; p < 0.0001).