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. 2007 Jul 18;27(29):7869–7878. doi: 10.1523/JNEUROSCI.0649-07.2007

Figure 4.

Figure 4.

The effect of Alprazolam and chloral hydrate on sleep and on rousability in R6/2 and WT mice. A, Alprazolam (black symbols) had a hypnotic effect on both R6/2 (circles) and WT (squares) mice that was pronounced at 1 h and had worn off by 4 h. C, Chronic treatment with Alprazolam from 4 weeks of age improved predosing rousability in R6/2 mice. This effect lasted for several weeks (D; data shown for 60 s after cage opening). R6/2 mice treated with chloral hydrate (black symbols) showed residual sedation, both before (data not shown) and 4 h after drug injection (B; data shown for 60 s after cage opening). *p < 0.05, **p < 0.01, and ***p < 0.001: statistical significance of Alprazolam- or chloral hydrate-treated R6/2 mice compared with vehicle-treated R6/2 mice.