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. 2007 Jul 18;27(29):7869–7878. doi: 10.1523/JNEUROSCI.0649-07.2007

Figure 7.

Figure 7.

The effect of Alprazolam treatment on mRNA expression of clock genes in the SCN. Expression profiles are shown of mBmal1 (A, B), mPer2 (C, D), and mProk2 (E, F) from vehicle-treated (A, C, E) and Alprazolam-treated (B, D, F) mice. Significant differences were seen in expression levels of these genes in the SCN of vehicle-treated R6/2 mice (open circles) compared with vehicle-treated WT mice (open squares). In R6/2 mice, Alprazolam reversed the dysregulated gene expression of mPer2 (D) and mProk2 (F).