Figure 7.
Temporal and lamina distribution of the fate-mapped interneuron subtypes. A–J, Histograms showing the normalized distribution of each cell type over the four time points of tamoxifen administration (E9.5, E10.5, E12.5, E15.5). A, B, Classical FS (A) and dFS (B) interneurons together; FS interneurons were the major class found in this study, representing ∼50% of fate-mapped interneurons at all time points examined. dFS interneurons were found more from the E15.5 fate mapping (B). C, D, rIB (C) and iIB (D) subtypes of interneurons were fate mapped from only early time points. E, F, Within two of the NFS interneurons, NFS1 (E) peaked at the E12.5 time point. G–J, Three subtypes of dNFS2 (H), LS (I), and iAD (J) interneurons were mainly found in the E15.5 fate mapping. dNFS1 (G) interneurons were the only subtype to exhibit a bimodal distribution. K, The location of interneurons in deep versus superficial laminar distribution primarily reflected the time point at which interneurons were fate mapped. Interneuron subtypes predominantly fate mapped from the E15.5 time point (H–J) showed a preferential location in superficial layers (K).