Skip to main content
. 2007 Jul 18;27(29):7817–7826. doi: 10.1523/JNEUROSCI.1026-07.2007

Figure 3.

Figure 3.

Somatic development and grip strength. A, Body weight measured at 2.4 months before water maze testing was reduced in APP-KO (13 KO and 15 wt) regardless of gender, but not in APPΔCT15-KI (17 KI and 16 wt) nor in APPsα-KI (17 KI and 16 wt) mice. ANOVA: genotype × line, F(2,58) = 5.1 (p < 0.0092); genotype × line × gender, F(2,58) = 1.3, ns. APP-KO: genotype, F(1,16) = 31.2 (p < 0.0001); genotype × gender, F(1,16) = 2.7, ns. APPΔCT15-KI: genotype, F(1,21) = 0.1, ns; genotype × gender, F(1,21) = 0.1, ns. APPsα-KI: genotype, F(1,21) = 0.7, ns; genotype × gender, F(1,21) = 0.8, ns. B, Brain weight at 10–12 months of age was strongly reduced in APP-KO mice (9 KO and 10 wt). This effect was attenuated in the APPΔCT15-KI (12 KI and 10 wt) and fully corrected in the APPsα-KI line (12 KI and 10 wt). ANOVA: genotype × line, F(1,29) = 4.9 (p < 0.0151). APP-KO: genotype, F(1,9) = 31.4 (p < 0.0003). APPΔCT15-KI: genotype, F(1,12) = 6.5 (p < 0.0253). APPsα-KI: genotype, F(1,8) = 0.3, ns. C, Grip strength was strongly reduced in APP-KO mice (13 KO and 15 wt) in both test sessions on consecutive days. This effect was fully corrected in the APPΔCT15-KI (17 KI and 16 wt) and attenuated in the APPsα-KI line (17 KI and 16 wt). ANOVA: genotype × line, F(2,58) = 9.0 (p < 0.0004); genotype × line × session, F(2,58) = 0.7, ns. APP-KO: genotype, F(1,16) = 52.4 (p < 0.0001); genotype × session, F(1,16) = 0.7, ns. APPΔCT15-KI: genotype, F(1,21) = 0.4, ns; genotype × session, F(1,21) = 0.3, ns. APPsα-KI: genotype, F(1,21) = 7.3 (p < 0.0136); genotype × session, F(1,21) = 1.3, ns.