Figure 3.

Network-driven activity recorded from ventral interneurons after 1 and 2 weeks in slice cultures or recorded from E15 and E19.5 spinal cords. A, B, Spontaneous activity in control solution is shown both at 7 DIV (A, top) and E15 (A, bottom) and at 14 DIV (B, top) and E19.5 (B, bottom). Note the developmental changes in firing patterns from bursting to nonbursting. In neurons recorded at 14 DIV, this switch in network activity was accompanied by a large increase in firing frequency. VRrL5, Right L5 VR.