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. 2007 Jan 24;27(4):852–859. doi: 10.1523/JNEUROSCI.4244-06.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/270852-08$15.00/0

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Figure 5. — Bax deletion does not affect axon and myelin degeneration in Tg(F35) mice. Toluidine blue-stained, semithin, plastic sections of white matter from the cervical spinal cord were prepared from terminally ill, 90-d-old mice in group 1 (F35^+/0 Prn-p^0/0 Bax^+/0) (A), group 2 (F35^+/0 Prn-p^0/0 Bax^0/0) (B), group 3 (F35^+/0 Prn-p^+/0 Bax^+/0) (C), or group 4 (Prn-p^+/0 Bax^+/0) (D) mice. Axonal loss, vacuolation, and myelin collapse are visible in groups 1 and 2 mice, whereas groups 3 and 4 mice show no abnormalities. Scale bar (in A) A–D, 20 μm.