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. 2007 Jan 24;27(4):852–859. doi: 10.1523/JNEUROSCI.4244-06.2007

Figure 7.

Figure 7.

Bax deletion does not affect cerebellar pathology in Tg(ΔCR) mice. Cerebellar sections from mice in groups 1–4 at 25 d of age were stained with hematoxylin and eosin (A–D), TUNEL (red) and DAPI (violet) (E–H), or an antibody against GFAP (I–L). All mice had the Prn-p+/0 genotype. Mice from group1 (A, E, I) and group 2 (B, F, J) show substantial granule cell loss, numerous TUNEL-positive granule cells, and prominent astrogliosis. Normal granule cell density with small numbers of TUNEL-positive granule cells and mild astrogliosis are seen in group 3 mice (C, G, K), whereas no abnormalities are apparent in group 4 mice (D, H, L). GL, Granule cell layer; ML, molecular layer. Scale bars: (in A) A–D, 250 μm; (in E) E–H, 50 μm; (in I) I–L, 100 μm.