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Lamina I: temperature coding. Both NS (A) and WDR (B) neurons encoded noxious thermal stimuli in wt (filled bars) and mutant animals (open bars), but the responses of the NS neurons in the mutant mice are significantly reduced compared with the wt (*p < 0.05, **p < 0.01, ***p < 0.001 vs control; ##p < 0.01 between genotypes). Error bars indicate SEM.
