Table 1.
Inhibitory potency of P2 receptor antagonists in the guinea pig isolated urinary bladder
| PPADS |
Suramin |
|||
|---|---|---|---|---|
| IC50 (95% cl) (μm) | nH | IC50 (95% cl) (μm) | nH | |
| 4 Hz, 20 s | 6.9 (1.3–38.3) | 0.57 | 13.4 (6.6–27.5) | 0.75 |
| 2 Hz, 20 s | 3.7 (1.1–13.1) | 0.77 | 16.2 (5.3–49.3) | 0.77 |
| α,β-meATP (1 μm) | 5.0 (4.3–6.0) | 1.04 | 22.5 (14.9–34.1) | 1.08 |
| ATP (300 μm) | 6.0 (1.8–19.8) | 0.99 | 15.4 (6.0–39.6) | 0.80 |
Values shown are IC50 and 95% confidence limits (95% cl) (in micromolar) and the Hill slopes (nH) obtained by fitting the Hill equation to responses obtained in the presence of the antagonists. n = 3–8.