Figure 2.

APP/PS2 mice show elevated brain levels of IGF-IR and increased AMPK activity. A, A slight but significant increase was observed in IGF-IR levels in mutant mice that was normalized by IGF-I treatment. B, Insulin receptor (IR) levels were slightly elevated in mutant mice and remained elevated after IGF-I treatment. C, Brain levels of pAMPK (the active form of the kinase) were significantly elevated in APP/PS2 mice. Representative blots and/or densitometric histograms are shown. *p < 0.05; ***p < 0.001; n ≥ 4 per group.