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. 2007 Aug 8;27(32):8581–8592. doi: 10.1523/JNEUROSCI.0192-07.2007

Figure 5.

Figure 5.

Early defects in the dopaminergic neuron precursors. A–G, M–O, Whole-mount mRNA in situ hybridization analysis of Aldh1 (A–G) and Pitx3 (M–O) expression in wild-type (WT), Fgfr1cko (R1cko), Fgfr1cko;Fgfr2cko (R1cko;R2cko), and Fgfr1cko;Fgfr2cko;Fgfr3null (R1cko;R2cko;R3null) embryos. Lateral views (anterior rightwards) are shown. The embryos have been sagittally bisected after staining. H–L, ALDH1 immunohistochemistry on coronal sections at E9.5 and E11.5 in the WT, Fgfr1cko;Fgfr2cko, and Fgfr1cko;Fgfr2cko;Fgfr3null embryos. Red arrows indicate changes in DA neurons and their precursors in the mutants. I, Red arrowhead shows residual ALDH1 expression. DAPI, 4′,6′-Diamidino-2-phenylindole. Scale bars: (for H–J) H, (for K, L) K, 100 μm.