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. 2007 Aug 8;27(32):8581–8592. doi: 10.1523/JNEUROSCI.0192-07.2007

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Copyright © 2007 Society for Neuroscience 0270-6474/07/278581-12$15.00/0

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Figure 8. — Decreased expression of the regulators of proliferative neural progenitor cells. Whole-mount mRNA in situ hybridization analysis of CyclinD1 (A–F), CyclinD2 (G, H), p21 (I, J), and Sox3 (K–P) expression in the wild-type (WT), Fgfr1^cko;Fgfr2^cko (R1cko;R2cko), and Fgfr1^cko;Fgfr2^cko;Fgfr3^null (R1cko;R2cko;R3null) embryos at E9.0–E9.5. Lateral views (anterior rightwards) are shown. Red arrows indicate downregulated CyclinD, p21, and Sox3 mRNA expression, whereas red arrowheads mark residual expression in the mutants.