Figure 6.

Overexpression of wild-type and R275W parkin in parkin null flies exert different effects on dopaminergic neuronal survivability. A, Bar graph showing the number of dopaminergic (DA) neurons in different clusters of 20-d-old hparkin/− and R275W/− flies, as depicted by different shades shown in the figure. Data for control and parkin null flies were derived from Figure 2 (*p < 0.05, **p < 0.01, Student's t test; n = 10). B, Representative confocal microscopy images showing TH-positive (red) dopaminergic neurons in the PPL1 cluster of 20-d-old old hparkin/− and R275W/− flies, as indicated. C, Bar graph showing the climbing scores of the various mutant flies, as indicated, at 20 d after eclosion (*p < 0.05, **p < 0.01, Student's t test; n = 20) (genotype: UAS-hParkin, park¹/park¹, Ddc-Gal4, control Ddc-Gal4/+).