Figure 2.

A, Distribution of commonly regulated genes according to functional class. B, Genes related to immune function regulated in neuropathic pain models in the dorsal horn. Data shown for each gene are SNI (red circles), CCI (green squares), or SNL (blue triangles) after injury. Each plot is on a log base 2 scale, with the origin zero equivalent to onefold (nonregulation). The rat gene abbreviation, the maximum difference from the origin on the log base 2 scale, and conversion to linear scale are as indicated beneath each plot. Genes are sorted according to peak upregulation. C1qb, C1qg, C3, and C4 complement components; Aif1, Allograft inflammatory factor 1 (Iba1); Ctss, cathepsin S; Ctsh, cathepsin H; CCR5, C-C chemokine receptor 5; Ifngr, interferon-γ receptor 1; Cx3cr1, chemokine (C-X3-C motif) receptor 1.